![Mapping Cancer Cell Infiltration and Migration in an Organoid Model](/images/projects/2021-12-02-MatsNilsson2021-2.gif)
Mapping Cancer Cell Infiltration and Migration in an Organoid Model
The objective of this study is to create a human cancer proliferation and progression model for glioblastoma. To create the model, cerebral organoids cultivated from human induced pluripotent stem cells were cocultured with fluorescent reporter...
![Detecting multiple protein interactions in cancerous tissue using in situ PLA](/images/projects/2021-06-01-UlfLandegren2021-1.png)
Detecting multiple protein interactions in cancerous tissue using in situ PLA
In this project, we set out to establish a method to detect multiple protein interactions and protein activation states in different types of cancerous tissue. Building on our long tradition of molecular tools development, we...
![Immunoprofiling of different subtypes of lymphoma using multiplex immunofluorescence](/images/projects/2021-02-03-GunillaEnblad2021-1.jpg)
Immunoprofiling of different subtypes of lymphoma using multiplex immunofluorescence
Competition with unshod horses is an important and hot topic in harness racing in Sweden. The performance, when racing unshod, improve markedly compared to the shod condition but trainers and owners are also aware of...
![Automatic motion artifact detection for in vivo confocal image stacks](/images/projects/2020-10-08-MiaPhillipson2020-1.png)
Automatic motion artifact detection for in vivo confocal image stacks
Acquisition of 4D in vivo confocal data from anesthetized mice is a complex task that involves overcoming a myriad of challenges such as proper surgical preparation, monitoring of vital physiological parameters of the anesthetized animal...
![Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells](/images/projects/2020-08-31-JohanKreuger2020-1.jpg)
Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells
Amoeboid cell migration, facilitated by the formation of dynamic plasma membrane blebs, is implicated in cancer cell migration, particularly in compressive environments such as those found in growing tumors. Blebbing is initiated by localized dissociations...
![Image analysis of cardiovascular and metabolic risk factors in 10 day-old zebrafish larvae.](/images/projects/2020-08-01-MarcelDenHoed2020-1.png)
Image analysis of cardiovascular and metabolic risk factors in 10 day-old zebrafish larvae....
The den Hoed research group at IGP has acquired imaging data for traits related to cardiovascular and metabolic diseases in >25,000 larvae since 2014. Image analysis pipelines have previously been developed for these...
![Functional analysis of cardiomyocytes derived from pluripotent stem cells](/images/projects/2020-03-12-AgnetaBroberg2020-1.png)
Functional analysis of cardiomyocytes derived from pluripotent stem cells
The aim of the project is to study the contractile and electrophysiologic characteristics of cardiomyocytes derived from human induced pluripotent stem cells after exposure to physiological stress and toxic substances. Pluripotent Stem Cells...