Detecting multiple protein interactions in cancerous tissue using in situ PLA
In this project, we set out to establish a method to detect multiple protein interactions and protein activation states in different types of cancerous tissue. Building on our long tradition of molecular tools development, we...
Signaling activation patterns in NSCLC detected by in situ PLA
Lung cancer is the most common cause of cancer mortality in Sweden and the overall prognosis is poor, with non-small cell lung cancer (NSCLC) representing 85% of all cases. Meanwhile, the underlying processes leading to...
Role of endogenous GDNF in ALS mouse model
We hypothesize that increased expression of endogenous GDNF from its native locus may alleviate ALS symptoms
Redox homeostasis regulation induces cardiomyocytes atrophy or hypertrophy
We aim to measure cell geometry alterations by florescence microscopy and to correlate that to molecular data obtained from the same treated cells.
NPC-incorporated structured hydrogels to aid neural cell therapy
Aim: To gain knowledge concerning hydrogel potential in neural progenitor cell (NPC) therapy.
In situ Sequencing for Visualization of Tumour Clonal Evolution
Clonal evolution, whereby a single cell in the tumor randomly acquires a mutation conferring a survival benefit followed by expansion of the offspring of this cell in the tumor as a consequence of selection, is...
Ecotoxicology-on-a-chip
Quantification of the effects of multiple physico-chemical stressors on the metabolism of single cells.
Immunoprofiling of different subtypes of lymphoma using multiplex immunofluorescence
Competition with unshod horses is an important and hot topic in harness racing in Sweden. The performance, when racing unshod, improve markedly compared to the shod condition but trainers and owners are also aware of...
Primary cilia in nervous system development
Segmentation of primary cilia in nervous system development
Horse hoof analysis
This project aims for investigating potential morphological differences between horse that are able to compete unshod and horses that need to have shoes during races.
Automatic motion artifact detection for in vivo confocal image stacks
Acquisition of 4D in vivo confocal data from anesthetized mice is a complex task that involves overcoming a myriad of challenges such as proper surgical preparation, monitoring of vital physiological parameters of the anesthetized animal...
Cancer-induced vascular changes
Lymph node tumor metastasis is one of the most important prognostic factors in human cancer and correlate with an increased risk for further metastatic spread in several types of cancer, including breast cancer and pancreatic...
Quantification of vessel and vessel lumen area in tissue sections
In a list of fluorescent images of mouse lymph nodes, we want to measure the total area of the lymph nodes, the total area of lymphatic vessels and the total area of the lumen within...