
Implementing high content screening of chromatin organization in live cells
In cells of the human body, inactive heterochromatin tends to distribute in the periphery of the cell nucleus, whereas active euchromatin is mostly localized in the nuclear interior. This spatial organization essential for...

Droplet microfluidics for detection of bacterial heteroresistance
Antibiotic resistance is a serious medical challenge that puts patients at risk of untreatable bacterial infections and threatens major advances in modern medicine that rely on antibiotics. To tackle this problem, innovative diagnostic...

A spatial single-cell type map of adult human spermatogenesis
Spermatogenesis involves the transformation of adult spermatogonial stem cells into fully developed sperm cells, which is governed by the testis niche/microenvironment. The cells must maintain a balance between renewing themselves and becoming differentiated, and then...

Digitizing historical range maps to estimate range shifts of Nordic vascular plants
Quantifying range changes and, importantly, understanding their drivers is vital in a time of ongoing biodiversity change. In this project we use image registration techniques together with GIS analyses to digitize historical range maps of...

Mapping of B cell phenotypes in distinct immune neighborhoods in sarcoma
Immunotherapy has lately gained increased attention in sarcoma, but response rates are highly diverse. Therefore, it is essential to identify patient selection criteria and define whether the tumor microenvironment contains responsive immune cells....

TGFβ family imaging - Simultaneous quantification of RNA levels (RNAscope) and protein levels...
Transcriptomic analysis of normal human and cancer cells revealed that the transforming growth factor β (TGFβ) signaling pathway regulates the expression of about 2,000 genes, including protein-coding and non-coding RNAs. Our group uses...

In Situ Sequencing of entorhinal cortex in Alzheimer’s disease
The entorhinal cortex is especially relevant for Alzheimer’s disease (AD) pathology. AD initiates in this region at the earliest disease stages, even before the first clinical symptoms appear. Within the entorhinal cortex, layer II excitatory...

Mapping Cancer Cell Infiltration and Migration in an Organoid Model
The objective of this study is to create a human cancer proliferation and progression model for glioblastoma. To create the model, cerebral organoids cultivated from human induced pluripotent stem cells were cocultured with fluorescent reporter...