Mapping Cancer Cell Infiltration and Migration in an Organoid Model
The objective of this study is to create a human cancer proliferation and progression model for glioblastoma. To create the model, cerebral organoids cultivated from human induced pluripotent stem cells were cocultured with fluorescent reporter...
Microgel microfluidic platform
We are within this project developing an in vitro method for interaction studies between the constituents of the subcutaneous tissue and different pharmaceuticals.
Chromosome dynamics in live yeast cells
The goal of this project is study chromosome organization in live cells and to understand how the spatial organization is affected by inactivation of SMC complexes.
Detecting multiple protein interactions in cancerous tissue using in situ PLA
In this project, we set out to establish a method to detect multiple protein interactions and protein activation states in different types of cancerous tissue. Building on our long tradition of molecular tools development, we...
Signaling activation patterns in NSCLC detected by in situ PLA
Lung cancer is the most common cause of cancer mortality in Sweden and the overall prognosis is poor, with non-small cell lung cancer (NSCLC) representing 85% of all cases. Meanwhile, the underlying processes leading to...
Role of endogenous GDNF in ALS mouse model
We hypothesize that increased expression of endogenous GDNF from its native locus may alleviate ALS symptoms
Redox homeostasis regulation induces cardiomyocytes atrophy or hypertrophy
We aim to measure cell geometry alterations by florescence microscopy and to correlate that to molecular data obtained from the same treated cells.
NPC-incorporated structured hydrogels to aid neural cell therapy
Aim: To gain knowledge concerning hydrogel potential in neural progenitor cell (NPC) therapy.
In situ Sequencing for Visualization of Tumour Clonal Evolution
Clonal evolution, whereby a single cell in the tumor randomly acquires a mutation conferring a survival benefit followed by expansion of the offspring of this cell in the tumor as a consequence of selection, is...
Ecotoxicology-on-a-chip
Quantification of the effects of multiple physico-chemical stressors on the metabolism of single cells.